Investigating Helicobacter pylori biofilm formation and its potential role in pathogenesis in the lab of Dr. Karen Ottemann. I'm using transcriptomic and genetic approaches to identify genes associated with H. pylori biofilm growth. We also use mouse-models for H. pylori infections and imaging approaches (CSLM and SEM) to characterize the biofilm structure its components.
1. Novel genes associated with Helicobacter pylori biofilm growth. S. Hathroubi and K. M Ottemann. In preparation.
2. The Helicobacter pylori biofilm state involves multi-gene stress-biased response including a structural role of flagella. S. Hathroubi and K. M Ottemann. 2018. mBio (published, DOI: 10.1128/mBio.01973-18).
3. Helicobacter pylori biofilm formation and its potential role in pathogenesis. S. Hathroubi, S. L. Servetas, I. Windham, D. S. Merrell, K. M Ottemann. 2018. Microbiology and Molecular Biology Reviews (Published, DOI: 10.1128/MMBR.00001-18)